We previously showed that TBK1 is a gene that causes glaucoma by altering autophagy. Autophagy is a process by which cells engulf and digest cell components. Cells may use autophagy as a source of energy in times of nutritional deprivation. We have shown that TBK1 gene defects (duplications and triplications) cause excess autophagy, which can damage vital cell components and lead to cell death and ultimately to glaucoma. This new publication outlines standards for the research community to follow when studying autophagy. Read the guidelines here.
Fingert Lab NewsMonday, January 25, 2016 - 11:00
Fingert Lab NewsFriday, January 15, 2016 - 10:15
As part of the NEIGHBORHOOD consortium of glaucoma genetics labs in the US, we co-authored a Nature Genetics report that identified three new risk factors for glaucoma: TXNRD2, ATXN2, and FOXC1. The discovery of more risk factors is a significant step forward in the science and care of glaucoma. Read more about it here.
Fingert Lab NewsMonday, December 14, 2015 - 19:15
Lab contributes to an article reviewing discussions focusing on the exfoliation glaucoma at the Glaucoma Foundation’s Glaucoma Think Tank in New York.” Read more about this article here.
Fingert Lab NewsWednesday, December 2, 2015 - 09:00
The Glaucoma Genetics lab has been awarded a grant from the National Eye Institute to study glaucoma caused by the TBK1 gene using a stem cell approach. The two year R21 grant entitled “TBK1-Related Glaucoma” will provide resources for the lab to collect skin cells from patients with low pressure glaucoma caused by a TBK1 gene defect. These skin cells will be reprogrammed to become pluripotent stem cells which then will be used to produce cells that have features of the optic nerve - the tissue damaged by glaucoma. This study will allow Glaucoma Genetics Lab members to study the steps by which defects in the TBK1 gene damage the optic nerve and cause glaucoma. Moreover these studies will also lay the groundwork for testing new treatments for TBK1-related glaucoma as well as developing restorative optic nerve therapies.
Key Investigators in this project are John Fingert and Budd Tucker and their post-doctoral fellow Tasneem Sharma.
Fingert Lab NewsTuesday, November 17, 2015 - 10:15
Fingert Lab NewsTuesday, November 3, 2015 - 10:45
Image above, NCMD-lesion.
Lab contributes to the discovery of two genes for North Carolina Macular Dystrophy. Read more about this here.
Fingert Lab NewsTuesday, September 1, 2015 - 13:30
Studies of two large families with nanophthalmos identified mutations in the TMEM98 gene that lead to development of abnormally small eyes that is a dominantly inherited trait. Read more about it here.
Fingert Lab NewsTuesday, July 28, 2015 - 20:45
Read more about it here.
Fingert Lab NewsThursday, July 2, 2015 - 08:45
Dr. Fingert was recognized for his service and contributions to ophthalmic research by being named a Fellow of the Association for Research in Vision and Ophthalmology (FARVO). Read more about it here.
Fingert Lab NewsTuesday, May 26, 2015 - 10:00
Ralph Hazlewood, completed his PHD working on the genetics of optic nerve disease in The Glaucoma Genetics Lab at the University of Iowa. He is pictured with his graduate school advisor, John Fingert, at graduation ceremonies on May 22. Dr. Hazlewood will continue his training as a post-doctoral fellow in Doctor Rachel Kuchtey’s laboratory at Vanderbilt University.